ジアゼパムの通常予想される作用と反対の反応、つまり、易興奮性、筋痙攣、そして（極端な場合）憤激や暴力が起きる可能性がある。これは「奇異反応」と呼ばれる。こうした反応があった場合、ただちにジアゼパムを中止しなければならない。こうした効果から、身体における耐性と精神的な依存が引き起こされうる。[要出典]
ジアゼパムはまれに、フェニトイン（アレビアチン）の代謝を阻害し、その作用（と副作用）を増強する。
The worst section was that I under no circumstances understood when or in which my seizures would occur, if they would be tiny or big, or simply even worse, become a cluster.
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If essential, a second dose can be provided no less than 4 hrs following the primary dose, using a new pack of VALTOCO. Will not give in excess of 2 doses of VALTOCO to treat a seizure cluster.
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